Log inGet your card
Log in

Get your medical card online in minutes!

Get started

Explore A-Z conditions

Cannabis for endometriosis

Endometriosis is a condition in which tissue similar to the lining of the uterus grows in other areas of the body. It often leads to intense, crippling pain, especially during periods (menstruation).

It affects more than 11% of women between the ages of 15 and 44 in the United States, totaling approximately 6.5 million individuals.

Emerging evidence suggests that compounds in medical cannabis, like the cannabinoids cannabidiol (CBD) and tetrahydrocannabinol (THC), may help people manage endometriosis symptoms, including chronic pain, inflammation, sleep difficulties, and mood changes.

alternate crochet image of ovary

Research on cannabis for endometriosis

Research on cannabis for endometriosis is still in its early stages, but some studies show promising benefits.

Two studies from 2021 and 2024 reported that cannabis treatment helped patients manage pelvic and period pain, respectively. Another study found that inhalable cannabis products, in particular, reduced pelvic pain.

Research also shows that many people might already be using cannabis for their endometriosis symptoms. One review of eight studies found that cannabis is commonly used by women with endometriosis, and many used it to reduce the need for other pain medications. A 2024 study including 912 patients had similar results, with 1 in every 8 women reporting that they use cannabis to reduce pain medication intake and to manage pain, discomfort, or sleep problems.

While these findings are encouraging, larger human studies are needed to fully understand cannabis’ role in managing endometriosis and to find the best way to dose THC and CBD for treatment.

Using cannabis for endometriosis

Cannabis can be useful if you’re looking for alternatives to traditional endometriosis pain management options. However, it’s important to weigh the potential benefits against the risks and consider your unique health needs.

You should always speak with your healthcare team to make sure you’re using cannabis in a safe and effective way.

Benefits

Medical cannabis may benefit those managing endometriosis symptoms in several ways, including:

  • Supports general pain management: THC and CBD can effectively reduce chronic pelvic pain and period cramps.
  • Reduces dryness and local pain: CBD applied locally to the vagina (e.g., in tampons or suppositories) may help manage vaginal dryness and menstrual pain associated with endometriosis.
  • Lowers inflammation: CBD’s anti-inflammatory properties may help reduce swelling associated with endometriosis.
  • Improves mood: Cannabinoids may relieve stress, anxiety, and depression, which are common among people with chronic pain.
  • Supports fertility: Some research shows cannabinoids may regulate anandamide levels, a compound that plays a role in fertility.
  • Reduces medication intake: Many women using medical cannabis for endometriosis-related pain report reducing their intake of other pain medications.

Risks and side effects

As with any other medication, medical cannabis can have side effects. These include:

  • Mood changes: THC may cause euphoria, anxiety, or paranoia in some individuals.
  • Fatigue: Cannabis use can lead to drowsiness or a lack of energy.
  • Gastrointestinal issues: Some users report nausea or changes in appetite.
  • Dependence: Long-term use carries the potential for dependence or misuse.

Cannabis is federally illegal, but medical cannabis is legal in many states. To access medical cannabis, you need to be diagnosed with a qualifying condition by a physician and apply for a medical card.

Endometriosis is listed as a qualifying condition under the North Dakota Medical Marijuana Program. In other states, you may qualify based on a symptom of endometriosis, such as chronic pain.

Best strains and products for endometriosis

You can look for specific cannabis strains and products to help with endometriosis symptoms, but it’s important to remember that most recommendations are based on anecdotal reports and the little research that exists. More research is needed to understand exactly which types are ideal.

Strains and products high in limonene, linalool, myrcene, and CBD may be best for people with endometriosis. Moderate levels of THC may also help you manage pain, insomnia, and appetite loss.

Inhaling cannabis is reported to be the most popular method for rapid pain relief. Tinctures can also provide relief from general pain. Orally ingested products are fairly popular and offer longer-lasting effects.

Topicals, transdermal patches, vaginal suppositories, and infused tampons can provide targeted relief for localized pain.

Combining these methods may optimize pain management tailored to your needs.

Strains (aka cultivars)

The best strains for endometriosis pain are those high in CBD, such as ACDC and Charlotte’s Web, or balanced THC:CBD strains like Cannatonic, as they can offer pain relief, anti-inflammatory effects, and mood-balancing benefits.

THC:CBD ratios

For those sensitive to THC, a high-CBD product with a 1:3 ratio of THC to CBD or above may be ideal. A balanced 1:1 THC to CBD ratio could be better for those with a higher THC tolerance.

Terpenes

Terpenes are chemicals in cannabis that provide some additional therapeutic effects.

Many terpenes have anti-inflammatory, antioxidant, stress-relieving, and mood-altering effects that could be helpful for endometriosis, including:

  • Beta-caryophyllene: Offers anti-inflammatory effects
  • Limonene: May be useful for mood enhancement
  • Linalool: Promotes relaxation
  • Myrcene: Supports pain relief

Strains including Aloha Limonene, Jilly Bean, or Lavender contain high levels of these terpenes.

Flavonoids

Flavonoids are compounds in cannabis that contribute to its flavor, smell, and color. Quercetin and kaempferol are two cannabis flavonoids that might help slow the advancement of endometriosis. However, research is still in its early stages.

More about endometriosis

The exact cause of endometriosis is unknown, but researchers believe it’s related to problems with the immune system, hormone balance, and menstruation. Clinical endocannabinoid deficiency (CECD) — a state in which the body doesn’t produce enough cannabinoids — is another potential factor.

Common symptoms include severe period cramps, chronic pelvic pain, painful intercourse, and infertility. More than 60% of people with endometriosis experience chronic pelvic or abdominal pain, while up to 80% report painful periods.

Diagnosis typically involves medical history, pelvic exams, imaging, and sometimes minor surgery called laparoscopy.

The outlook for endometriosis varies. Some people find relief after menopause, while others face ongoing challenges.

Other treatments for endometriosis

Although there is no cure for endometriosis, there are medications and treatments that may reduce pain and slow the growth of the condition.

Traditional therapies

  • Hormonal birth control: Birth control containing hormones is commonly used to regulate periods and reduce pain.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs): Pain medications, including aspirin, ibuprofen, and naproxen, are commonly recommended for endometriosis pain.
  • Surgery: In severe cases, laparoscopic surgery may be necessary to remove endometrial tissue.

Natural and alternative therapies

  • Acupuncture: Repeated sessions of acupuncture may reduce endometriosis pain and improve quality of life.
  • Herbal remedies: Curcumin, chamomile, and ginger are commonly used for their anti-inflammatory properties.
  • Dietary changes: Anti-inflammatory eating patterns, such as the Mediterranean diet, may help reduce inflammation-related symptoms.

Always speak with your healthcare team about natural or alternative therapies you’re interested in using.

cbd oil with weed, different pens and marijuana leaf around it

Cannabis as part of your treatment plan for endometriosis

Medical cannabis can support your endometriosis treatment, offering a holistic approach to symptom management and potentially reducing the need for other prescription medications.

With any type of cannabis, it’s ideal to start with a very low dose and increase slowly over time as needed. An initial low dose may look like 2 to 3 milligrams (mg) of THC. You can then take another dose every 1 to 2 hours, if needed, to get symptom relief without experiencing overwhelming psychoactive effects.

CBD isn’t intoxicating, so many people tolerate it better than THC. Still, a high dose of CBD (50 mg or higher) may cause drowsiness.

If you’re considering cannabis as part of your treatment plan, speak with a healthcare provider to receive personalized guidance and explore getting a medical marijuana card.

Frequently asked questions

Get answers to your FAQs regarding medical cannabis use and endometriosis.

Does weed help with period cramps?

There’s evidence that cannabis — aka weed — can help with period cramps. Both THC and CBD have pain-relieving and anti-inflammatory properties that can ease cramping and pain associated with menstruation.

Research shows that inhaled products, such as vaporizers and smoked cannabis flower, are particularly popular for period cramps. Their fast onset time may offer rapid relief from pain.

Can I use CBD for endometriosis?

CBD can be helpful for managing inflammation and improving mood in those with endometriosis. However, some may require THC and other cannabinoids to experience the full range of cannabis’ beneficial effects.

Can I get a medical card for endometriosis?

Yes, depending on where you live. While not every state recognizes endometriosis as a qualifying condition, many do recognize chronic pain and other common endometriosis symptoms. Check your state’s list of qualifying conditions and speak with a physician about getting certified for medical marijuana. Or, opt for a telehealth service like Leafwell to get certified from home.

Resources

Get your medical marijuana card

Research Overview

Animal Study

3

Clinical Trial

1

Laboratory Study

1

Meta-analysis

11

Total studies

endometriosis

16

Positive

13 studies

81%

Inconclusive

3 studies

19%

Do I qualify?

Select your state from the drop down and we’ll let you know.

Relevant studies

The information in our comprehensive A to Z encyclopedia comes from real scientific studies.

Uncover the detailed results of these studies and find out how effective medical marijuana is for dozens of conditions.

Table of content

  1. Research on cannabis for endometriosis
  2. Using cannabis for endometriosis
  3. Is it legal?
  4. Best strains and products for endometriosis
  5. More about endometriosis
  6. Other treatments for endometriosis
  7. Cannabis as part of your treatment plan for endometriosis
  8. Frequently asked questions
  9. Resources
  10. Research Overview
  11. Relevant studies